The Isezakicho Washington Hotel Yokohama is located in Isezakicho Yokohama near by Chinatown, providing easy access to the main terminal at Yokohama Station, which is close to Yokohama Port. The Haneda Airport is located approximately 22 kilometres away whereas the Narita International Airport is located approximately 101 kilometres away from the hotel.

Isezakicho Washington Hotel Yokohama is located:

- 5 minutes from Kannai Station, JR Keihin Tohoku / Negishi Line;

- In front of Isezaki-Chojamachi Station, Yokohama Subway Line;

- 7 minutes from Yokohama Station on the JR Line or Yokohama Subway Line;

- 30 minutes from Haneda Airport to Yokohama Station on the Keikyu Line;

- and 90 minutes by Limousine Bus from Narita Airport to JR Yokohama Station (Yokohama City Air Terminal).